![]() The recent discovery of two m 6A demethylases in mammalian cells highlighted the importance of m 6A in basic biological functions and disease 6, 7, 8. Although essential to cell viability and development 3, 4, 5, the exact role of m 6A modification remains to be determined. After the synthesis of protein (translation), transfer RNA (tRNA) is not deactivated or destroyed, it is reused in next process.N 6-methyladenosine (m 6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes 1, 2. Each transfer RNA (tRNA) attaches to one specific amino acid and transport it. Transfer RNA (tRNA) also serve as the link between the coding sequences of messenger RNA (mRNA) and amino acids. These amino acids are specific as they are further utilized for specific protein synthesis. It takes amino acids with it and transports it through the cytoplasm to the ribosomal RNA (rRNA) present on ribosomes. It is found only In the cytoplasm of the cell not in the nucleus. Transfer RNA (tRNA) is that type of RNA that transfer amino acids to the ribosome for the synthesis of proteins. Transfer RNA (tRNA) is 15% of total RNA in cells. Its structure is bit complex as compared to messenger RNA (mRNA), it has 75-95 nucleotides in it. Transfer RNA (tRNA) is the third and the smallest type of RNA found in the cell. In post-transcriptional changes messenger, RNA (mRNA) is capped with guanosine triphosphate nucleotide at its 5’ end and same, to the 3’ end of messenger RNA (mRNA) multiple adenylate residues are added. Messenger RNA (mRNA) carries the gene in the form of triplets of DNA bases, after the process of synthesis of proteins (translation) messenger RNA (mRNA) is deactivated and broken down. Structurally, messenger RNA (mRNA) are the simple strands of DNA sequence and stores genetic codes in it. Then proteins are synthesized according to the information on messenger RNA (mRNA). Amino acids needed for protein synthesis are provided by transfer RNA (tRNA). Ribosomal RNA acts as a factory for protein synthesis. In the cytoplasm, messenger RNA (mRNA) moves to ribosome onto which ribosomal RNA (rRNA) is attached. Here it gets all the genetic information from DNA by transcription and then moves to the cytoplasm. Messenger RNA (mRNA) is the first type of RNA found in the cell, 5% of total RNA in the cell is messenger RNA (mRNA). Another difference is that messenger RNA (mRNA) is found in the nucleus and cytoplasm of cell whereas, transfer RNA (tRNA) is found only in the cytoplasm. Messenger RNA (mRNA) are the simple strands of DNA sequence and stores genetic codes in it whereas, transfer RNA (tRNA) are complex and looped structure. Structurally, messenger RNA (mRNA) and transfer RNA (tRNA) are quite different. Whereas, transfer RNA (tRNA) is the type of RNA that transfer amino acids to the ribosome for the synthesis of proteins. Messenger RNA (mRNA) is the type of RNA which contain genetic information in the form of codons that are transcribed from DNA in nucleus and transport this information to the ribosome. Here we are dealing with messenger RNA (mRNA) and transfer RNA (tRNA). RNA has further three types, messenger RNA (mRNA), transfer RNA (tRNA) and ribosomal RNA (rRNA). It is one of the type of nucleic acid found in cells. ![]()
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